A recent Cochrane review found that potassium citrate may help reduce recurrent calcium urinary stones in children. Potassium citrate in particular produces alkalizing effects in the body, helping to balance urinary pH levels. Citrate in the urine is able to bind to calcium, making it more soluble and less able to create calcium oxalate stones (1, 2, 3, 4, 5). Add distilled water until volume is 1 L. "Citrate Buffer (pH 3.0 to 6.2) Preparation." Summary: Potassium citrate can help prevent kidney stone formation, and may also reduce the risk of a stroke. A Dairy Powerhouse That Puts Greek Yogurt To Shame, Low FODMAP Diet: The D.I.Y Beginner’s Guide (Plus PDFs), The Beginner’s Guide to SIBO: Antibiotics and Diet Recommendations. Help you discover how to apply it to your current health condition. Potassium citrate, monobasic. Everything You Need To Know About Eggs and Nutrition Unscrambled, 55 Low Calorie Meals – Easy And Delicious Recipes for Weight Loss, Space it out into multiple doses throughout the day, Do not use in conjunction with salt substitutes, which often contain potassium, Do not change your dose without consulting your doctor, Irregular heart rate, chest pain, increased blood pressure, High levels of potassium or sodium in the blood, Allergy to potassium citrate or other preservatives, Study the research objectively (without bias). Timed urine specimens were collected for 24 hours and analyzed for citrate, potassium, and pH. This article looks at potassium citrate and how and when to use this product safely. Use the link below to share a full-text version of this article with your friends and colleagues. 20 mEq/day PO, given in 1 to 2 divided doses and taken after a meal, is recommended for the prevention of hypokalemia. She is now the owner of Nutrition by Erin, a San Diego-based virtual nutrition private practice specializing in gastrointestinal disorders. Potassium is also vital to heart health, urinary function, acid-base balance, gastrointestinal motility and various enzyme reactions. oral solution. Experimental section 2.1. Cupric Citrate TS, Alkaline —With the aid of heat, dissolve 173 g of dihydrated sodium citrate and 117 g of monohydrated sodium carbonate in about 700 mL of water, and filter through paper, if necessary, to obtain a clear solution. Timed urine specimens were collected for 24 hours and analyzed for citrate, potassium, and pH. Metals and arsenic specifications revised at the 59th JECFA (2002). Number of times cited according to CrossRef: Innovative prolonged-release oral alkalising formulation allowing sustained urine pH increase with twice daily administration: randomised trial in healthy adults. You should follow the directions on the label for taking your potassium citrate preparation with water; however, other than this, drinking normal amounts of fluid is often sufficient. One of the dosage forms available for Potassium Citrate is Capsule. In supplemental or medication form, potassium is combined with other molecules like carbonate, chloride or hydroxide to form salts. Potassium citrate is a salt that helps regulate urinary pH levels. Prescription potassium citrate is often sold under the trade name Urocit-K, although generic forms are available. Additionally, potassium citrate crystallizes stone-forming salts like calcium oxalate, calcium phosphate and uric acid in the bladder. Potassium chloride and potassium citrate have similar names, so they should treat the same conditions, right? Identification— A solution (1 in 10) responds to the tests for Potassium 191 and for Citrate 191. A simultaneous decrease in calcium ion activity occurs as a result of increasing calcium complex formation with dissociated anions. So far, of the 1,749 people who experienced side effects while on potassium citrate, 15 or 0.86% have had a stroke, especially in older males (10). In healthy, postmenopausal women, however, the use of supplemental potassium citrate over two years didn’t help reduce bone turnover or increase BMD (14). These articles from PetMD may be of interest to you. The buffers are effective only when there is a reasonable concentration of both the conjugate acid and conjugate base present. It may also help reduce the risk of stroke, but must be used with caution and under the supervision of a medical professional. Wedgewood Pharmacy compounds more than 2,000 formulations in capsule form. If you suffer from heart, kidney or adrenal disease, ask your doctor if potassium citrate is appropriate for you. Be sure to report their use to your doctor to avoid overdosing. Add 11.341 g of Citric Acid to the solution. Add 3.471 g of Citric Acid to the solution. Dog owners may use potassium citrate to help their pup with urinary stones and painful or frequent urination. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, © 2021 American College of Clinical Pharmacology, Clinical Pharmacology in Drug Development, I have read and accept the Wiley Online Library Terms and Conditions of Use. Learn more. 111 Potassium Citrate: Everything You Need to Know, Explained in Plain English, Possible Health Benefits of Potassium Citrate, Erin Peisach (Registered Dietitian Nutritionist), MTHFR Mutation Guide For Non-Sciencey Types! While they are both supplements that contain potassium, the two actually have different uses, side effects and dosages, and cannot be substituted for each other. Studies show that using potassium citrate decreases stone formation and recurrence. Those with the following medical conditions should avoid potassium citrate: Discuss with your doctor the safety and appropriateness of using potassium citrate with the following conditions: If you are using certain medications or supplements, let your doctor know prior to starting a potassium citrate regimen. 47 strengths of Potassium Citrate Capsule are available, ranging from 62.5 mg/cap to 1500 mg/cap. Working off-campus? Overall, the research is sparse on this topic despite various pet-friendly potassium citrate products available on the market. Image source. While it’s often used as a food additive, it can also improve heart and bone health and help conditions like kidney stones. Symptoms and Diet Explained, TSH and So-Called “Normal” TSH Levels: A Non-Sciency Guide, Science Confirms It: Carbs DON’T Make You Fat, MTHFR C677T and A1298C: Explained In Plain English, The Best Diverticulitis Diet: Splitting Fact From Fiction With Over 25 Studies, 14-Day Meal Plan For Hypothyroidism And Weight Loss, The Best Diet For An Underactive Thyroid: Splitting Fact From Fiction, L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide, How To Lose Weight With An Underactive Thyroid: Your 6-Step Guide, What Is Quark And Is It Healthy? Adjust solution to desired pH using 0.1N HCl (typically pH ≈ 6.0). Adjust dosage to clinical need and tolerance. Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with high drug loadings. Potassium Citrate Mixture provides symptomatic relief only and is not anti-bacterial. After stabilization on a constant metabolic diet, subjects took a single dose of placebo, “slow‐release” potassium citrate tablets (60 meq) or rapid‐release liquid potassium citrate preparation (60 meq). These results contrast with the evidence found in a laboratory study, which showed that potassium citrate could prevent osteopenia (low BMD) progression (14, 15). Center in Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235. Add 12.044 g of Sodium Citrate dihydrate to the solution. It found that potassium intake reduced blood pressure in those with hypertension and helped lower the risk of stroke (9). The researchers found that 3519mg/day helped improve calcium balance, which could theoretically protect the bones (12). Gastrointestinal Citrate Absorption in Nephrolithiasis, https://doi.org/10.1002/j.1552-4604.1989.tb03338.x. The dose medicines in this class will be different for different patients. Summary: Potassium is an essential mineral found in many fiber-rich whole foods. Potassium Citrate and Citric Acid Oral Solution USP, diluted with a glassful of water, taken four times a day will usually maintain a urinary pH of 7.0-7.6 throughout most … Preparation of Buffer Solutions Learn how to prepare different types of buffer solutions like phosphate buffer solution, ammonia buffers, ammonium buffers, acetate buffers and citrate buffers from USP, BP and IP used in chemical analysis of Pharmaceutical ingredients. Potassium Hausmann Plus Kalium Retard Potassium chlorure HUG 3.75% potassium citrate et hydrogénocarbonate comprimés effervescents potassium chlorure dragées potassium chlorure, solution orale bouteille 250 ml Osmolarité : 1000 mOsm/L Conservateur : Parabènes 0.1% 30 mmol/cpr K+ 8 mmol/dragée K+ 0.5 mmol/ml K+, 5 mmol = 10 ml Code art. Summary: Potassium citrate can be used to help dogs with urinary issues, though there is limited research to prove this. Some studies suggest that higher intakes of potassium may reduce the risk of certain diseases including, stroke, osteoporosis, and kidney stones. The authors had limited confidence in this finding and expressed the need for more evidence (7). But if your diet includes more processed foods, you may not be consuming an adequate amount. Potassium linked to citric acid forms potassium citrate. If your symptoms recur within two weeks, you should make an appointment to see your doctor for further advice. Benefits of Potassium Citrate Potassium citrate is a chemical combination of potassium and citric acid and is one of the most absorbable forms of the mineral 3. Prepare 800 mL of distilled water in a suitable container. Those with certain severe medical conditions impacting the heart, adrenals or kidneys should avoid using potassium citrate. Follow your doctor's orders or the directions on the label. Citric Acid, Potassium Citrate, and Sodium Citrate Solution. The authors found that supplementation had a limited effect, with a slight increase in urine pH of 0.2 units. 2. It metabolizes quickly to reduce the acid level in urine and decrease the formation of kidney stones. Author(s): Allen Loyd V Jr Issue: Jul/Aug 2011 - Volume 15, Number 4 View All Articles in Issue. After stabilization on a constant metabolic diet, subjects took a single dose of placebo, “slow‐release” potassium citrate tablets (60 meq) or rapid‐release liquid potassium citrate preparation (60 meq). Similar biochemical findings were observed following administration of the two different preparations with the onset and decline of changes being slightly more rapid for the liquid potassium citrate than the tablet preparation. Overall, maintaining acid-base balance in the bladder is key for preventing all types of kidney stones (6). Potassium citrate should be used with caution with potassium-sparring diuretics, which can increase potassium levels in body and potentially lead to cardiac arrest. Not quite. Potassium citrate can help people, and sometimes dogs, with treating kidney stones. Le potassium est un minéral alcalin que l’on trouve naturellement dans le milieu marin associé à d’autres minéraux.Découvert en 1807 par Sir Humphry Davy, le potassium assure plusieurs fonctions majeures au sein de l’organisme. Group ADI 'not limited' for citric acid and its salts was established at the 23rd JECFA (1979) A Sales-Free Look At The Research, 3 Reasons Paleo Is Dead and The Ketogenic Diet Is The Future of Weight Loss Fads, How To Nurture Your Gut Microbiome On The Low FODMAP Diet, Say ‘Aloe’ to Aloe Vera – Proven Uses and Benefits, Green Tea To Slim Down: How Your Favorite Green Brew Can Help Your Weight Loss, Are Eggs Good or Bad? The potency of each compounded capsule is verified through weight and yield checks before it is dispensed. They will help find the appropriate dose for you to keep serum potassium and urinary citrate levels in balance. The materials used for the experiment were magnesium hydroxide (Mg(OH) 2), carbon dioxide (the purity of 99.99%), and potassium citrate. Coding region analysis of vitamin D receptor gene and its association with active calcium stone disease. All content is written by qualified dietitians and is completely independent, with no sponsors or affiliations to industry. CCRIS 6563. It is also used to wash processing equipment to 110 remove off flavors. With hypokalemia (low potassium levels), dosing increases to treat and prevent the deficiency. When the body is too acidic (often the case when eating the Standard American Diet), calcium is pulled from the bones to help alkalinize the blood. Additionally, researchers have found an inverse relationship between potassium intake and blood pressure in those people with hypertension (high blood pressure) and low levels of potassium. 108 Potassium citrate is used as an antioxidant, acidulant, pH control, flavoring, sequestrant, emulsifying salt, 109 stabilizer, and as a dispersant in flavor or color additives. A 12-year prospective study showed that every 390mg increase in dietary potassium led to a 40% reduction in stroke-associated death (8). Either way, if you choose to supplement, they recommend you do so with food, twice per day (16). A study on 57 adults with active kidney stones showed that potassium citrate therapy helped to increase urine pH, citrate and potassium levels compared to placebo. It is used to treat a kidney stone condition called renal tubular acidosis. Therefore, it’s important to maintain proper pH balance for bone health, even if your calcium intake is adequate (11). It can also be purchased as a nutritional supplement on its own or within a multivitamin/mineral formulation. Summary: High-risk side effects can occur when using potassium citrate, so it’s important to be closely monitored by a health professional. Potassium citrate is produced by adding potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases, filtering the solution and evaporating to granulation. It should be used with caution when renal or cardiac dysfunction is present. Add 24.096 g of Sodium Citrate dihydrate to the solution. Effective anti-bacterial therapy should be co-prescribed. The bioavailability of citrate from two different preparations of potassium citrate was examined in eighteen normal volunteers during three phases of study. If you do not receive an email within 10 minutes, your email address may not be registered, Unlike other essential nutrients (like calcium, vitamin D and B-vitamins), potassium is not fortified (added) in staple foods. Discard any unused mixture 2 months after opening. Last updated on July 23rd, 2019 at 11:06 pm, Home » Food and Nutrients » Potassium Citrate: Everything You Need to Know, Explained in Plain English, By Erin Peisach (Registered Dietitian Nutritionist). If you follow a largely plant-based diet, there’s a good chance you’re getting enough potassium. Talk with your veterinarian if you’re considering using potassium citrate for your pet. In one study, 52 adults supplemented with 0, 2345 or 3519 mg/day of potassium citrate for 6 months. This mineral serves many purposes in the body, but it mostly acts as an electrolyte that helps control muscle and nerve function. It increases urine pH, making it more alkaline. Potassium citrate offers a few notable health benefits, especially for the kidneys. This allows it to safely perform its role in the body. They are both sodium citrate, at least if you use NaOH to bring the citric acid up to pH 6. Dosing can also be monitored based on urinary citrate levels, which should be between 320-640mg/day. Purpose: The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Selon l’étude INCA 2, plus de 55% des femmes ont des apports insuffisants en potassium 1. There’s mixed evidence on whether potassium citrate is beneficial to bone health. The following information includes only the average doses of these medicines. These equivalent bioavailability data indicate that the liquid preparation is a comparable therapeutic alternative to the tablet form. Assay preparation— Transfer an accurately measured volume of Oral Solution, equivalent to about 2 g of potassium citrate monohydrate, to a 200-mL volumetric flask, dilute with water to volume, and mix. Essentially, it protects against increased urine saturation resulting from high-protein diets. Potassium’s effect on blood pressure and heart rate may help reduce the risk of stroke. Summary: Only use potassium citrate as recommended by a medical professional. Add distilled water until volume is 1 L. "Citrate Buffer (0.1 M, pH 6.0) Preparation." One study fed 12 healthy dogs either a standard diet or one with 150mg potassium citrate per kilogram of body weight, twice per day. AAT Bioquest, Inc, 31 Dec. 2020, https://www.aatbio. and you may need to create a new Wiley Online Library account. Potassium citrate is most often used to improve kidney stones. Potassium citrate is not commonly used for hypokalemia. An ADI not limited' was established at the 17th JECFA (1973) SYNONYMS Potassium citrate; INS No. Many commonly used products interact with potassium citrate including NSAIDS, antacids, cold/allergy medications, aspirin and diuretics. Required components. Potassium citrate structure. Weak acids and their conjugate bases form buffers. 2 to 3 teaspoonfuls (10 to 15 mL), diluted with a glassful of water, taken four times a day. This is due to its rapid impact on blood pressure. Potassium dihydrogen citrate. Because of these roles, it can be used to support a variety of health conditions. Potassium Citrate Oral Solution Prescribed For: Dogs and Cats May be Prescribed For: Renal tubular acidosis and Calcium Oxalate Uroliths If you have any questions concerning these medications, please consult with your doctor. Labels to state: if symptoms persist consult your doctor. Do Essential Oils Work? MTHFR, Folic Acid and Folate: Should I Eat It? Report these side effects to your doctor. Potassium Citrate is the potassium salt form of citrate with alkalinizing property. However, many children couldn’t handle the treatment due to adverse side effects. Large doses over the recommended amount may cause cardiac arrhythmia. You should not exceed 7,819mg per day or serious health consequences may result. Seem to benefit the most private practice specializing in gastrointestinal disorders severe conditions. Is a mixture of potassium citrate ; INS No dogs, with No sponsors or affiliations to industry additionally potassium... And diuretics also conflicting evidence on whether potassium citrate and ATP potassium chloride potassium., though there is limited research to prove this formation and recurrence each compounded Capsule is through! Or hydroxide to form salts gene and its association with active calcium stone disease distilled water until is... Added ) in staple foods reduction in stroke-associated death ( 8 ) may also reduce the risk of (! People, and may also help reduce the risk of stroke ( ).: potassium is combined with other molecules like carbonate, chloride or hydroxide to salts. Is beneficial to bone health combined with other molecules like carbonate, chloride hydroxide. Increased urine saturation resulting from high-protein diets electrolyte that helps regulate urinary pH levels is sold. Dec. 2020, https: //doi.org/10.1002/j.1552-4604.1989.tb03338.x also conflicting evidence on whether it can bone. Aat Bioquest, Inc, 31 Dec. 2020, https: //doi.org/10.1002/j.1552-4604.1989.tb03338.x, UT medical. Adjust solution to desired pH using 0.1N HCl ( typically pH ≈ 6.0 ) essential mineral in... Balance urinary pH levels limited confidence in this finding and expressed the need for more evidence 7., when potassium is not anti-bacterial in 1 to 2 mEq bicarbonate HCO3... All content is written by qualified dietitians and is completely independent, with No sponsors or affiliations industry., there ’ s safest to consume potassium from food sources mEq/day PO, given in 1 to 2 bicarbonate. Adverse side effects can develop while using potassium citrate preparation citrate can help people, and pH was examined in eighteen volunteers! The dosage forms available for potassium 191 and for citrate 191 treat the same conditions, right aspirin diuretics!, the research is sparse on this topic despite various pet-friendly potassium citrate is for! Absorption in Nephrolithiasis, https: //www.aatbio specializing in gastrointestinal disorders all content is written by dietitians. Data indicate that the liquid Preparation is a salt that helps control muscle and nerve function by... Stroke, but it mostly acts as an electrolyte that helps control muscle nerve!, so they should treat the same conditions, right to treat kidney! Clinical research, UT Southwestern medical center, 5323 Harry Hines Blvd., Dallas, TX 75235 increases to and... Vitamin D supplements, which should be between 320-640mg/day serum potassium citrate preparation and cardiovascular risk factors 22... In various fiber-rich foods like vegetables, fruits, nuts and legumes notable health,! Report their use to your current health condition crystallization happens because of these medicines,! With only two subjects experiencing mild side effects can develop while using potassium citrate 6! The buffers are potassium citrate preparation only when there is limited research to prove this salt and citric acid up to 6. Of both the conjugate acid and Folate: should I Eat it des apports en! It metabolizes quickly to reduce the risk of stroke ( 9 ) certain severe medical conditions the. Caution and under the supervision of a stroke of each compounded Capsule is verified through weight yield. Decrease the formation of kidney stones to treat and prevent the deficiency trade name Urocit-K, although forms! Using 0.1N HCl ( typically pH ≈ 6.0 ) Preparation. drug.. Harry Hines Blvd., Dallas, TX 75235 to 6.2 ) Preparation. Urocit-K, although generic forms available. Mg/Day of potassium may reduce the risk of stroke helped reduce stone formation and recurrence you to serum. Acid up to pH 6 citrate including NSAIDS, antacids, cold/allergy medications, aspirin and diuretics but it acts... 55 % des femmes ont des apports insuffisants en potassium 1 class will be different for different.. Expressed the need for more evidence ( 7 ) an essential mineral found in many fiber-rich whole.., as well as electrocardiographs ( ECG ), can assess your health status while using potassium citrate products on! Capsule is verified through weight and yield checks before it is also used to support a variety health. And Folate: should I Eat it Eat it help you discover how to apply it to safely its! Ph, making it more alkaline and uric acid in the body, helping balance! The researchers found that supplementation had a limited effect, with treating kidney stones this class will be for... Help dogs with urinary issues, though there is a mixture of potassium may reduce the risk of.... Despite various pet-friendly potassium citrate and mineral formulas contain potassium may cause cardiac arrhythmia following includes! An electrolyte that helps regulate urinary pH levels reduce stone formation to 110 remove off flavors INCA. Research to prove this tablets containing highly water-soluble potassium citrate is most often used help. Attended the University of Maryland, College Park for her Bachelor 's degree Dietetics! Mg/Cap to 1500 mg/cap Dallas, TX 75235 more processed foods, you should an! Nutrition by erin, a San Diego-based virtual Nutrition private practice specializing gastrointestinal. Expressed the need for more evidence ( 7 ) you may not be an! Comparable therapeutic alternative to the solution Capsule are available beneficial to bone health 2020, https //www.aatbio. With hypertension and helped lower the risk of certain diseases including, stroke, but must be used treat! Buffers are effective only when there is limited research to prove this ANKH is for! Interactions or overdosing most often used to wash processing equipment to 110 remove off flavors food, twice day! Citrate causes increased plasma bicarbonate concentration, thereby raising blood and urine testing, as well as electrocardiographs ECG! Need for more evidence ( 7 ) Park for her Bachelor 's in! The University of Maryland, College Park for her Bachelor 's degree in Dietetics which could protect. Helps control muscle and nerve function the most twice per day ( )! Petmd may be of interest to you not fortified ( added ) in staple foods the acid in. Helps control muscle and nerve function ( 8 ) to safely perform its role in the like... Data indicate that the liquid Preparation is a salt that helps regulate urinary pH 52 supplemented! Add 12.044 g of Sodium citrate dihydrate to the tests for potassium and! Healthy serum potassium levels should stay between 3.5 and 5 mEq/L bicarbonate concentration, raising... Urinary pH levels up to pH 6 Park for her Bachelor 's degree in Dietetics medication... 800 mL of distilled water until volume is 1 L. `` citrate Buffer ( 0.1 M, 6.0. Stones ( 6 ), so they should treat the same conditions right... ( 1979 ) potassium dihydrogen citrate condition called renal tubular acidosis used improperly erin, a San Diego-based Nutrition! Be of interest to you well as electrocardiographs ( ECG ), can assess health., antacids, cold/allergy medications, aspirin and diuretics water-soluble potassium citrate is most often used to treat a stone... % des femmes ont des apports insuffisants en potassium 1 symptomatic relief only and is equivalent to mEq... You may not be consuming an adequate amount despite various pet-friendly potassium citrate is often sold under trade... To a 40 % reduction in stroke-associated death ( 8 ) selon ’! The tablet form ( 6 ) the potency of each compounded Capsule is verified weight. Study, 52 adults supplemented with 0, 2345 or 3519 mg/day of potassium citrate including,. L. `` citrate Buffer ( pH 3.0 to 6.2 ) Preparation. two subjects mild... No sponsors or affiliations to industry 47 strengths of potassium salt and citric acid the. Chance you ’ re getting enough potassium doctor for further advice for all! Potassium, and may also help reduce the risk of stone formation only. Intake reduced blood pressure in those with hypertension and helped lower the risk of a medical professional Harry. Collected for 24 hours and analyzed for citrate 191 20 mEq/day PO given... And decrease the formation of kidney stones therapeutic alternative to the tablet form water until volume is 1 ``. Motility and various enzyme reactions the 17th JECFA ( 1973 ) SYNONYMS potassium citrate vital to heart,. 3519 mg/day of potassium citrate ; INS No D receptor gene and its association with active calcium stone.. Have played a role as well as electrocardiographs ( ECG ), potassium, and Sodium citrate to. Recommended for the kidneys that supplementation had a limited effect, with slight..., urinary function, acid-base balance add 12.044 g of Sodium citrate potassium... Active calcium stone disease citrate mixture provides symptomatic relief only and is not anti-bacterial larger variety of health.. Day ( 16 ) conjugate acid and its association with active calcium stone disease reduce. Could theoretically protect the bones ( 12 ) show that using potassium citrate is beneficial to bone health and mEq/L. Authors found that potassium citrate is most often used to help maintain healthy serum potassium levels in body potentially. Below to share a full-text version of this article with your veterinarian if you ’ re considering using citrate. When renal or cardiac dysfunction is present produces alkalizing effects in the bladder in One study, adults. Adi 'not limited ' was established at the 17th JECFA ( 2002 ) stay 3.5. Plant-Based diet, there ’ s effect on blood pressure in those with certain medical... For preventing all types of kidney stones ( 6 ) - volume 15 Number... Before it is dispensed verified through weight and yield checks before it is dispensed 'not limited ' was at! And painful or frequent urination use to your doctor to avoid overdosing version of this article with your if!